paper yasser
binding free energy, we showed that the binding of TopBP1 to GINS is mediated by two low affinity interfaces, namely TopBP1-GINI and TopBP1-BRCT45. TopBP1 utilises a bipartite GINS binding mode to support genome [...] biomolecular interactions involved. TopBP1 and GINS form a complex essential to build a macro-complex that recruits essential elements for genome replication. TopBP1 is a multi-domain biomolecule that establishes [...] domains of TopBP1 have been identified as important for genome duplication. By employing AlphaFold modeling and molecular docking, we independently predicted the GINS binding site of the TopBP1-GINI domain …